Research Abstract
Our research is focused on the design and application of bioinformatics algorithms to elucidate global regulatory mechanisms in normal development and diseases such as cancer. We have a solid track record in large-scale genomics data analysis and the development of widely used open-source bioinformatics software, such as MACS (>9,000 citations) for ChIP-seq and RSeqQC (>1,200 citations) for RNA-seq. In collaboration with experimental biologists, we have used bioinformatics to gain novel biological insights into development, aging, stem cell, neurologic disorders, and various cancers.