基本信息
浏览量:10
职业迁徙
个人简介
Research Abstract
My research seeks answers to the question how circulating blood cells find their way in the body. Directed migration of blood-borne cells to distinct target tissues can be observed in embryos as soon as the circulatory system is established and plays a critical role throughout life in numerous physiologic and pathologic conditions. Despite considerable progress in this field, it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that determine blood cell behavior in microvessels. Therefore, we employ intravital microscopy to study the molecular mechanisms of interactions between blood cells and the vascular wall by direct observation in anesthetized mice. Using this approach, we have demonstrated that blood cell homing to most target tissues requires an initial tethering step that leads to rolling in postcapillary venules and is followed by an activation step which, in turn, triggers stationary adhesion and emigration. Each of these three steps (i.e. 1. rolling; 2. chemotactic stimulation; and 3. firm arrest) involves distinct molecular pathways whose unique combination is the reason why certain blood cells migrate to a particular organ, whereas others don't.
My research seeks answers to the question how circulating blood cells find their way in the body. Directed migration of blood-borne cells to distinct target tissues can be observed in embryos as soon as the circulatory system is established and plays a critical role throughout life in numerous physiologic and pathologic conditions. Despite considerable progress in this field, it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that determine blood cell behavior in microvessels. Therefore, we employ intravital microscopy to study the molecular mechanisms of interactions between blood cells and the vascular wall by direct observation in anesthetized mice. Using this approach, we have demonstrated that blood cell homing to most target tissues requires an initial tethering step that leads to rolling in postcapillary venules and is followed by an activation step which, in turn, triggers stationary adhesion and emigration. Each of these three steps (i.e. 1. rolling; 2. chemotactic stimulation; and 3. firm arrest) involves distinct molecular pathways whose unique combination is the reason why certain blood cells migrate to a particular organ, whereas others don't.
研究兴趣
论文共 411 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Samuel W. Kazer, Colette Matysiak Match, Erica M. Langan, Marie-Angèle Messou,Thomas J. LaSalle, Elise O’Leary, Jessica Marbourg, Katherine Naughton,Ulrich H. von Andrian,Jose Ordovas-Montanes
biorxiv(2024)
Sarah L. Price,Robert S. Oakes, Rodrigo J. Gonzalez,Camilla Edwards, Amanda Brady,Jennifer K. DeMarco,Ulrich H. von Andrian,Christopher M. Jewell,Matthew B. Lawrenz
ISCIENCEno. 1 (2024): 108600-108600
Rodrigo J. Gonzalez, Pavel Hanc,David Alvarez,Samuel W Kazer,Marie-Angele Messou,Irina B Mazo, Colette Matysiak Match,Rohit Garg,Jennifer D. Helble,Paris Pallis, Rachel Ende,Alan Basset,
biorxiv(2024)
Behnaz Eshaghi,Alex Schudel,Ilin Sadeghi,Ziqi Chen, Amy H. Lee,Maria Kanelli, Flora Tierney,Jooli Han,Bailey Ingalls,David M. Francis, Gary Li,Ulrich von Andrian,
Nature Reviews Materialsno. 1 (2024): 29-45
Molecular Therapyno. 5 (2024): 1425-1444
Cell Researchpp.1-2, (2024)
Soeren Lammers, Victor Barrera, Philip Brennecke,Corey Miller,Joon Yoon,Jared Balolong,Mark S. Anderson,Shannan Ho Sui,Lars M. Steinmetz,Ulrich H. von Andrian,Kristin Rattay
FRONTIERS IN IMMUNOLOGY (2024): 1277365-1277365
Apoorvi Chaudhri,Xia Bu,Yunfei Wang, Michael Gomez,James A Torchia,Ping Hua,Shao-Hsi Hung, Michael A Davies,Gregory A Lizee,Ulrich von Andrian,Patrick Hwu,Gordon J Freeman
Frontiers in immunologyno. Suppl 1 (2023): 1237715
Ahmed A Raslan,Tho X Pham,Jisu Lee,Jeongmin Hong, Jillian K Schmottlach, Kristina Nicolas, Mehmed D Taha,Andreea M Bujor,Nunzia Caporarello,Aude Thiriot,Ulrich H von Andrian,Steven K Huang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn