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Pathogenetic and therapeutic aspects of chronic cholestatic and immune-mediated liver diseases
The pathophysiology of chronic cholestatic and immune-mediated liver diseases like primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis, IgG4-related cholangitis and various genetic cholestatic disorders is still only partly understood. Patients may suffer from fatigue, pruritus and various other symptoms. Most of these diseases have a progressive course without adequate treatment leading to cirrosis and complications of portal hypertension. Evidence-based therapies are now available for some of these diseases such as primary biliary cholangitis, autoimmune hepatitis or IgG4-related disease, but many more efforts are needed to disclose the pathophysiological mechanisms leading to these diseases as well as the symptoms like pruritus and fatique. Using the full spectrum of laboratory techniques, ranging from basic biochemistry and in vitro cell biology to mouse models, translational studies and clinical trials with affected patients, we try to gain more insight in the pathophysiology of, and possible novel therapeutic approaches towards cholestatic and immune-mediated liver diseases.
Pathogenetic and therapeutic aspects of chronic cholestatic and immune-mediated liver diseases
The pathophysiology of chronic cholestatic and immune-mediated liver diseases like primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis, IgG4-related cholangitis and various genetic cholestatic disorders is still only partly understood. Patients may suffer from fatigue, pruritus and various other symptoms. Most of these diseases have a progressive course without adequate treatment leading to cirrosis and complications of portal hypertension. Evidence-based therapies are now available for some of these diseases such as primary biliary cholangitis, autoimmune hepatitis or IgG4-related disease, but many more efforts are needed to disclose the pathophysiological mechanisms leading to these diseases as well as the symptoms like pruritus and fatique. Using the full spectrum of laboratory techniques, ranging from basic biochemistry and in vitro cell biology to mouse models, translational studies and clinical trials with affected patients, we try to gain more insight in the pathophysiology of, and possible novel therapeutic approaches towards cholestatic and immune-mediated liver diseases.
研究兴趣
论文共 472 篇作者统计合作学者相似作者
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Hepatology (Baltimore, Md.) (2024)
FRONTIERS IN IMMUNOLOGY (2024): 1251134-1251134
Journal of hepatologyno. 3 (2024): 387-389
Roni F. Kunst,Isabelle Bolt, Rychon D. J. van Dasselaar, Bart A. Nijmeijer,Ulrich Beuers,Ronald P. J. Oude Elferink,Stan F. J. van de Graaf
JHEP REPORTSno. 1 (2024): 100917-100917
Anna E. C. Stoelinga,Maarten E. Tushuizen, Wilbert B. van den Hout, Mar D. M. Rodriguez Girondo,Elsemieke S. de Vries, Amar D. Levens,Dirk-Jan A. R. Moes,Tom J. G. Gevers,Suzanne van der Meer, Hans T. Brouwer,Hendrik J. M. de Jonge, Ynte S. de Boer,
Trialsno. 1 (2024): 1-11
Anne Linde Mak, Nienke Wassenaar,Anne-Marieke van Dijk,Marian Troelstra,Veera Houttu,Koen van Son, Stan Driessen, Diona Zwirs,Sandra van den Berg-Faay,Elizabeth Shumbayawonda,Jurgen Runge,Michail Doukas,
JHEP Reportsno. 3 (2024): 100998-100998
Koos de Wit, Diederick J. van Doorn, Bregje Mol, Lonneke A. van Vught,Frederik Nevens,Ulrich Beuers,Cyriel Y. Ponsioen,Charlotte E. Teunissen,R. Bart Takkenberg
Annals of Hepatologypp.101496-101496, (2024)
Scandinavian journal of gastroenterologypp.1-8, (2023)
Journal of Hepatologyno. 4 (2023): 576-585
Scandinavian Journal of Gastroenterologyno. 8 (2023): 900-907
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