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Prof. Dr. Dr. Torsten Haferlach is CEO of MLL, a central reference laboratory providing diagnostic services for physicians in Germany that processes some 50,000 samples — mostly leukemias, myelodysplastic syndromes, and myeloproliferative neoplasms — each year. Three years ago, the institution adopted next-generation sequencing technologies to help keep up with demand to screen for molecular mutations; today, MLL is one of the largest 454 sequencing labs in Europe with seven instruments in accredited routine operations, and it has added two Illumina MiSeq instruments to its facility since the end of 2011.
According to Dr. Alexander Kohlmann, Laboratory Director for Next-Generation Sequencing at MLL, “The field is evolving to a situation where we’re no longer sequencing single genes but rather panels of genes.” Part of his job is to ensure that the laboratory can keep up with burgeoning demand from its customers. “Doctors are asking for information about many genes in parallel. They want the results for all these markers at the same time and not step by step,” he says, expecting a turn-around time of five to six days from sample receipt to sending out a report.
With that in mind, MLL has been developing a panel of genes linked to myeloid malignancies for research use on the RainDance Technologies targeted sequencing platform, starting with the RDT 1000 and more recently adding the higher-throughput ThunderStorm® instrument released this year.
The panel, which will be commercially available to other RainDance customers, consists of more than 25 genes. Haferlach and his team are targeting genes in which mutations are known to be medically actionable today based on information from scientific publications. “We developed the myeloid panel for research use in those malignancies where a lot of genes are already being requested today or where we see an unmet need to test these genes at a high level of sensitivity and throughput, providing actionable prognostic information to clinicians suitable to guide therapy in the near future,” Haferlach says.
研究兴趣
论文共 902 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2024): 1-1
Leukemiano. 2 (2024): 281-290
Georg Greiner,Nadine Witzeneder,Klara Klein,Simone Tangermann,Petra Kodajova,Eva Jaeger, Franz Ratzinger, Marlene C Gerner,Mohamad Jawhar, Sigrid Baumgartner, Karin Fruehwirth,Klaus G Schmetterer,
Bloodno. 11 (2024): 1006-1017
Armin P Piehler,Marietta Truger, Jan-Hendrik Kozik, Sandra Weissmann, Martin Schwonzen,Manja Meggendorfer,Wolfgang Kern,Torsten Haferlach,Gregor Hoermann,Claudia Haferlach
Haematologica (2024)
Nature Communicationsno. 1 (2024): 1-12
Francis Baumgartner, Constance Baer, Stefanos Bamopoulos,Edward Ayoub,Marietta Truger,Manja Meggendorfer,Miriam Lenk,Gregor Hoermann,Stephan Hutter,Heiko Müller, Wencke Walter, Martha-Lena Müller,
Bloodno. 12 (2024): 1139-1156
JCO clinical cancer informaticsno. 7 (2023)
Claudia Haferlach, Wencke Walter, Heiko Mueller, Sandra Huber, Constance Regina Baer, Stephan Hutter, Manja Meggendorfer, Gregor Hoermann, Wolfgang Kern,Torsten Haferlach
Blood (2023): 3170
Sandra Huber, Constance Regina Baer, Stephan Hutter, Gregor Hoermann, Christian Pohlkamp, Wencke Walter, Manja Meggendorfer, Wolfgang Kern,Torsten Haferlach, Claudia Haferlach
Blood (2023): 4609
Sandra Huber, Constance Regina Baer, Stephan Hutter,Frank Dicker, Irene Fuhrmann, Manja Meggendorfer, Christian Pohlkamp, Wolfgang Kern,Torsten Haferlach, Claudia Haferlach, Gregor Hoermann
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