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个人简介
MBBS (UCL) 1970; MRCP 1972; MD (University of London) 1978; FRCP 1988; MD honoris causa (University of Uppsala) 1995; FRCOG ad eundem 2000; FMedSci 2000
Stephen Franks is Professor of Reproductive Endocrinology at Imperial College Faculty of Medicine and Consultant Endocrinologist at St Mary’s Hospital (Imperial College Healthcare NHS Trust), London. He trained in Internal Medicine and Endocrinology and his initial research was in disorders of human prolactin secretion under the supervision of Howard Jacobs and John Nabarro at the Middlesex Hospital, London. He then spent 2 years as a postdoctoral research fellow in reproductive endocrinology in the lab of Dr Fred Naftolin at McGill University, Montreal (funded by an MRC Travelling Fellowship) before returning to resume his training in endocrinology with Bill Hoffenberg in Birmingham. He is a former Chairman of the Society for Endocrinology (UK), former President (and current Council member) of the Section of Endocrinology and Diabetes of the Royal Society of Medicine, a long-term member of the Society for Reproduction and Fertility and an honorary member of the British Fertility Society. He is a Fellow of the Academy of Medical Sciences and holds an honorary doctorate from the University of Uppsala, Sweden. He is a former editor of the journal, Clinical Endocrinology, Senior Editor for the journal Endocrine Connections and Associate Editor for the journal Reproduction.
Research interests
Ovarian physiology: control of follicle development in the mammalian ovary
Polycystic ovary syndrome: aetiology, reproductive and metabolic consequences
Stephen Franks has both clinic and laboratory-based programmes of research in the field of normal and disordered function of the hypothalamic-pituitary-ovarian axis. He has a major interest in polycystic ovary syndrome (PCOS), which is not only the commonest cause of anovulatory infertility but is also a major risk factor for development of type 2 diabetes. His research includes investigation of disorders of ovarian follicle development, the mechanism(s) of anovulation, and of the characteristic metabolic abnormalities; it focuses particularly on the interaction between genetic and environmental factors in the aetiology of the syndrome. .
His earlier studies in the field of PCOS have included work elucidating the wide prevalence and spectrum of presentation of the syndrome, which led to revision of the diagnostic criteria for PCOS. His team also described a disorder of energy balance (associated with insulin resistance) in women with PCOS and demonstrated that metabolic abnormalities in PCOS are linked to menstrual dysfunction. They were amongst the first to promote low-dose gonadotropin regimens for the safe treatment of infertility in women with PCOS, a procedure that has now been adopted worldwide. In laboratory-based studies his team found evidence for an intrinsic ovarian abnormality of steroidogenesis in PCO ovaries. Another important aspect of the work on PCOS (in collaboration with, first, Bob Williamson, later Mark McCarthy and, more recently, Cecilia Lindgren), has been the search for the genetic basis of PCOS. He is currently a member of the Steering Committee for the international consortium studying the genetics of PCOS which has recently published a large genome-wide association study (GWAS) identifying key susceptibility loci for PCOS. Together with Professor Kate Hardy, he described abnormalities in early follicular development in the polycystic ovary, and this team has shown that this phenomenon is associated with abnormal expression of growth factors implicated in follicle development.
Stephen Franks is Professor of Reproductive Endocrinology at Imperial College Faculty of Medicine and Consultant Endocrinologist at St Mary’s Hospital (Imperial College Healthcare NHS Trust), London. He trained in Internal Medicine and Endocrinology and his initial research was in disorders of human prolactin secretion under the supervision of Howard Jacobs and John Nabarro at the Middlesex Hospital, London. He then spent 2 years as a postdoctoral research fellow in reproductive endocrinology in the lab of Dr Fred Naftolin at McGill University, Montreal (funded by an MRC Travelling Fellowship) before returning to resume his training in endocrinology with Bill Hoffenberg in Birmingham. He is a former Chairman of the Society for Endocrinology (UK), former President (and current Council member) of the Section of Endocrinology and Diabetes of the Royal Society of Medicine, a long-term member of the Society for Reproduction and Fertility and an honorary member of the British Fertility Society. He is a Fellow of the Academy of Medical Sciences and holds an honorary doctorate from the University of Uppsala, Sweden. He is a former editor of the journal, Clinical Endocrinology, Senior Editor for the journal Endocrine Connections and Associate Editor for the journal Reproduction.
Research interests
Ovarian physiology: control of follicle development in the mammalian ovary
Polycystic ovary syndrome: aetiology, reproductive and metabolic consequences
Stephen Franks has both clinic and laboratory-based programmes of research in the field of normal and disordered function of the hypothalamic-pituitary-ovarian axis. He has a major interest in polycystic ovary syndrome (PCOS), which is not only the commonest cause of anovulatory infertility but is also a major risk factor for development of type 2 diabetes. His research includes investigation of disorders of ovarian follicle development, the mechanism(s) of anovulation, and of the characteristic metabolic abnormalities; it focuses particularly on the interaction between genetic and environmental factors in the aetiology of the syndrome. .
His earlier studies in the field of PCOS have included work elucidating the wide prevalence and spectrum of presentation of the syndrome, which led to revision of the diagnostic criteria for PCOS. His team also described a disorder of energy balance (associated with insulin resistance) in women with PCOS and demonstrated that metabolic abnormalities in PCOS are linked to menstrual dysfunction. They were amongst the first to promote low-dose gonadotropin regimens for the safe treatment of infertility in women with PCOS, a procedure that has now been adopted worldwide. In laboratory-based studies his team found evidence for an intrinsic ovarian abnormality of steroidogenesis in PCO ovaries. Another important aspect of the work on PCOS (in collaboration with, first, Bob Williamson, later Mark McCarthy and, more recently, Cecilia Lindgren), has been the search for the genetic basis of PCOS. He is currently a member of the Steering Committee for the international consortium studying the genetics of PCOS which has recently published a large genome-wide association study (GWAS) identifying key susceptibility loci for PCOS. Together with Professor Kate Hardy, he described abnormalities in early follicular development in the polycystic ovary, and this team has shown that this phenomenon is associated with abnormal expression of growth factors implicated in follicle development.
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2024)
Pei Chia Eng,Maria Phylactou, Ambreen Qayum, Casper Woods, Hayoung Lee, Sara Aziz,Benedict Moore,Alexander D. Miras,Alexander N. Comninos,Tricia Tan,Steve Franks,Waljit S. Dhillo,
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The Journal of clinical endocrinology and metabolism (2024)
Hamza Ikhlaq,Stephen Franks
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2023): 17-17
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Journal of the Endocrine Societyno. Supplement_1 (2023)
Endocrine Abstracts (2022)
Niamh S. Sayers,Priyanka Anujan,Henry N. Yu, Stephen S. Palmer,Jaya Nautiyal,Stephen Franks,Aylin C. Hanyaloglu
Frontiers in Endocrinology (2022)
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