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个人简介
My research is focused on fundamental structural molecular biology, specifically in the measurement of the conformational dynamics of proteins and the elucidation of the role that these motions play in protein folding and misfolding of both water-soluble and membrane proteins. Using a wide range of biophysical methods and combining these with protein chemistry, molecular biology, chemical biology and structural biology, my research focus over the last 30 years has been the delineation of the mechanisms by which proteins fold or misfold; how dynamic excursions enable proteins to self-associate into amyloid fibrils - the complex macromolecular assemblies associated with some of the deadliest human diseases; and how proteins fold into the bacterial outer membranes of Gram-negative organisms.
研究兴趣
论文共 484 篇作者统计合作学者相似作者
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Jaime Santos,Jorge Cuellar, Irantzu Pallarès,Emily J Byrd,Alons Lends,Fernando Moro, Muhammed Bilal Abdul-Shukkoor,Jordi Pujols,Lorea Velasco-Carneros,Frank Sobott, Daniel E Otzen,Antonio N Calabrese,
Journal of the American Chemical Society (2024)
Liam D. Aubrey,Natalia Ninkina,Sabine M. Ulamec,Natalia Y. Abramycheva,Eftychia Vasili, Oliver M. Devine,Martin Wilkinson, Eilish Mackinnon,Galina Limorenko,Martin Walko, Sarah Muwanga,Leonardo Amadio,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 2 (2024): e2309700120-e2309700120
Methods in Cell Biology (2024)
Nikolaos Louros,Martin Wilkinson,Grigoria Tsaka,Meine Ramakers, Chiara Morelli, Teresa Garcia,Rodrigo Gallardo, Sam D’Haeyer,Vera Goossens,Dominique Audenaert,Dietmar Rudolf Thal,Ian R. Mackenzie,
Nature Communicationsno. 1 (2024): 1-16
Leon F. Willis, Vishal Toprani, Sashini Wijetunge,Annette Sievers,Laura Lin, Jeanine Williams, Tom J. Crowley,Sheena E. Radford,Nikil Kapur,David J. Brockwell
JOURNAL OF PHARMACEUTICAL SCIENCESno. 3 (2024): 625-636
Angewandte Chemie International Editionno. 34 (2023)
Conny Leistner, M. K. Wilkinson, Ailidh Burgess,Megan Lovatt, S Goodbody,Yong Xu,Susan A. Deuchars,Sheena E. Radford,Neil A. Ranson,René Frank
EMPIAR dataset (2023)
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