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个人简介
Our lab of microbial genomics and systems biology focuses on the interactions between bacteria and the viruses that infect them (phages). We study how phages attack bacteria, and how bacteria defend themselves against such attacks. We are interested in deciphering the molecular mechanisms providing bacteria with protection against phages, collectively known as the "immune system" of bacteria. Specifically, we study the CRISPR-Cas system, as well as new anti-phage defense systems discovered in our lab. Our studies found that important components of the human innate immune system have originated from bacterial defense systems that protect from phages. We also discovered that phages can use small-molecule communication in order to coordinate their infection dynamics - our lab studies the molecular mechanisms allowing such communication.
Our research combines computational genomics techniques, systems biology, metagenomics, high-throughput sequencing technologies, and modern experimental approaches in microbiology and phage biology.
Current research directions in the lab include:
New defense systems and the arms-race between bacteria and phage
Communication between viruses
CRISPR-Cas, the adaptive immune system of bacteria and archaea
RNA-mediated regulation in microbes
Microbial genome evolution
Computational discovery of novel natural antibiotics
Our research combines computational genomics techniques, systems biology, metagenomics, high-throughput sequencing technologies, and modern experimental approaches in microbiology and phage biology.
Current research directions in the lab include:
New defense systems and the arms-race between bacteria and phage
Communication between viruses
CRISPR-Cas, the adaptive immune system of bacteria and archaea
RNA-mediated regulation in microbes
Microbial genome evolution
Computational discovery of novel natural antibiotics
研究兴趣
论文共 182 篇作者统计合作学者相似作者
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Erez Yirmiya,Azita Leavitt,Allen Lu,Adelyn E. Ragucci,Carmel Avraham, Ilya Osterman,Jeremy Garb,Sadie P. Antine, Sarah E. Mooney,Samuel J. Hobbs,Philip J. Kranzusch,Gil Amitai,
Natureno. 7994 (2024): 352-359
bioRxiv (Cold Spring Harbor Laboratory)no. 7994 (2024): 352-359
Ilya Osterman, Hadar Samra,Francois Rousset, Elena Loseva,Maxim Itkin,Sergey Malitsky,Erez Yirmiya,Adi Millman,Rotem Sorek
biorxiv(2024)
Natureno. 8003 (2024): 431-436
Benjamin R. Morehouse,Nitzan Tal,Nora K. McNamara-Bordewick,Alexander F. A. Keszei,Sichen Shao,Philip J. Kranzusch,Rotem Sorek
JOURNAL OF TRANSLATIONAL MEDICINEno. SUPPL 1 (2023)
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