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职业迁徙
个人简介
Ronald Hay is a molecular biologist who researches the role of a family of proteins called ubiquitins in the regulation of cellular processes. He established that a protein known as SUMO (small ubiquitin-like modifier) is important for the regulation of chemical activity within cells and has described several accepted models of how it acts. SUMO also plays a role in the action of chemotherapy drugs.
Through his research, Ron discovered that arsenic helps SUMO molecules to stick to proteins involved in the development of acute promyelocytic leukaemia. An enzyme that is attracted to SUMO then breaks down the cancer-causing proteins. This discovery could lead to the development of targeted drugs for cancer with fewer side effects.
Ron is now working to establish how SUMO responds to chemotherapy drugs, DNA damaging chemicals and cell signalling proteins. He is a member of EMBO, the European Molecular Biology Organization, and is also a Fellow of both the Royal Society of Edinburgh and the Academy of Medical Sciences.
研究兴趣
论文共 271 篇作者统计合作学者相似作者
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biorxiv(2024)
Julio C. Y. Liu,Leena Ackermann,Saskia Hoffmann, Zita Gal,Ivo A. Hendriks, Charu Jain, Louise Morlot,Michael H. Tatham,Gian-Luca Mclelland,Ronald T. Hay,Michael Lund Nielsen,Thijn Brummelkamp,
Marta Agostinho, Vera Santos,Fernando Ferreira, Rafael Costa,Joana Cardoso,Inês Pinheiro,José Rino,Ellis Jaffray,Ronald T. Hay,João Ferreira
crossref(2023)
PLoS pathogensno. 7 (2023): e1011477-e1011477
Emil P. T. Hertz, Ignacio Alonso-de Vega,Thomas Kruse, Yiqing Wang,Ivo A. Hendriks,Anna H. Bizard, Ania Eugui-Anta,Ronald T. Hay,Michael L. Nielsen,Jakob Nilsson,Ian D. Hickson,Niels Mailand
Nature structural & molecular biologyno. 9 (2023): 1303-1313
Wing-Hang Ip,Michael H. Tatham, Steewen Krohne, Julia Gruhne, Michael Melling,Tina Meyer, Britta Gornott,Luca D. Bertzbach,Ronald T. Hay,Estefania Rodriguez,Thomas Dobner
Journal of virology (2023)
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