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In general they focused on the basic biochemistry and pharmacological control of lipid mediators derived from both enzymatic and nonenzymatic pathways largely employing techniques of sophisticated mass spectrometry to address critical issues. The term lipid mediators is used here in the context that many of the compounds under investigation have potent and diverse biological activities that permit cells to intercommunicate with each other. For example, following exposure to reactive oxygen species new lipid molecules are formed from endogenous lipids by covalent alteration of their chemical structure and these new molecules cause cells in a tissue to respond to the oxidant stress. A major emphasis was to involve the use of mass spectrometry for both qualitative and quantitative investigations in this area of lipid biochemistry. Five specific areas the general focus of activities in this laboratory and they include:
1. Leukotriene biosynthesis
2. Transcellular biosynthesis of le ukotrienes
3. Studies of eicosanoid metabolism and studies of non-enzymatic lipid oxidation
4. Phospholipid remodeling and eicosanoid biosynthesis
5. Mass spectrometric studies of lipids, lipidomics, and imaging mass spectrometry
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Ravi P. Sahu,Jesus A. Ocana,Kathleen A. Harrison,Matheus Ferracini, Christopher E. Touloukian,Mohammed Al-Hassani, Louis Sun,Mathew Loesch,Robert C. Murphy,Sandra K. Althouse,Susan M. Perkins,Paul J. Speicher,
crossref(2023)
Ravi P. Sahu,Jesus A. Ocana,Kathleen A. Harrison,Matheus Ferracini, Christopher E. Touloukian,Mohammed Al-Hassani, Louis Sun,Mathew Loesch,Robert C. Murphy,Sandra K. Althouse,Susan M. Perkins,Paul J. Speicher,
crossref(2023)
crossref(2023)
Ravi P. Sahu,Jesus A. Ocana,Kathleen A. Harrison,Matheus Ferracini, Christopher E. Touloukian,Mohammed Al-Hassani, Louis Sun,Mathew Loesch,Robert C. Murphy,Sandra K. Althouse,Susan M. Perkins,Paul J. Speicher,
crossref(2023)
pubmed(2022)
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