基本信息
浏览量:3
职业迁徙
个人简介
Research Overview:
Our research focuses on the role of TGF-a and -b, two structurally related growth and differentiation factors, in epithelial and mesenchymal cell proliferation and differentiation. We use various cell biological, molecular and biochemical approaches to address cell physiological and developmental questions.
TGF-a is a growth factor for various cell types from ectodermal origin, including most epithelial cells, and exerts its functions in an autocrine and paracrine fashion. TGF-a is normally made as a transmembrane protein at the cell surface and functions in cell communication through its ability to interact with a tyrosine kinase receptor. The ectodomain can be proteolytically released in a highly regulated manner and is then released. Our TGF-a research focuses on the identification and functional characterization of proteins that form a complex in association with transmembrane TGF-a. We study their functions in the presentation of transmembrane TGF-a, signaling and regulation of TGF-a ectodomain cleavage in normal and transformed epithelial cells.
TGF-b is a prototype for a large family of growth and differentiation factors which regulate development. TGF-b is also a potent inducer of growth arrest in many cell types. Our research focus is on the mechanism of signaling by TGF-b receptors and its role in mesenchymal differentiation and apoptosis. We study how the Smads, a novel class of intracellular signaling effectors, act as signal transducers following receptor activation, are translocated into the nucleus and regulate gene expression. We also study how this signaling regulates mesenchymal cell differentiation into muscle, bone and fat cells, and cell death.
Primary Thematic Area:
Developmental & Stem Cell Biology
Secondary Thematic Area:
Cancer Biology & Cell Signaling
Research Summary:
Transmembrane TGF-a and TGF-b Receptor Signaling in Cell Proliferation and Differentiation
研究兴趣
论文共 195 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF CELL SCIENCEno. 22 (2022)
CELL SYSTEMSno. 9 (2022): 724-+
Nature Reviews Molecular Cell Biologyno. 12 (2021): 834-834
user-5f6bfffd92c7f9be21bbcc99(2021)
The Journal of Pathology (2021)
The Journal of pathologyno. 4 (2021): 358-373
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn