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个人简介
Professor Ralf Paus researches into the biology and pathology of the hair follicle, skin neuroendocrinology, and the science and applications of stem cells residing in human skin.
Research interests
Ralf researches into the biology and pathology of the hair follicle as a microcosmic miniorgan in which many of the fundamental problems of biology can be studied exemplarily. Currently, he is most intrigued by the astounding neuroendocrine properties of the human hair follicle, their impact on mitochondrial function and hair follicle immune status, and the use of adult hair follicle stem cells for regenerative medicine purposes.
Ralf's particular interest is in:
better defining and in manipulating various neuroendocrine pathways established in the human hair follicle (HPA and HPT axis equivalent systems) and in elucidating novel functions of this neuroendocrine activity, such as neuroendocrine controls of mitochondrial activity and biogenesis in human skin, stem cell biology, and wound healing
understanding the controls and functions of hair follicle immune privilege and its disorders that lead to alopecia areata or scarring alopecia
characterizing, selectively labelling, isolating and differentiating various stem cells populations associated with human scalp skin and its appendages
role of clock genes and olfactory receptors in the control of human hair growth and pigmentation
Methodologically, Ralf employs mainly human hair follicle and scalp skin organ culture, K15-GFP+ human epithelial hair follicle stem cells, and immunohistology/immunofluorescence, gene expression profiling, and analyzes the hair and skin phenotype of relevant mouse mutants.
Research interests
Ralf researches into the biology and pathology of the hair follicle as a microcosmic miniorgan in which many of the fundamental problems of biology can be studied exemplarily. Currently, he is most intrigued by the astounding neuroendocrine properties of the human hair follicle, their impact on mitochondrial function and hair follicle immune status, and the use of adult hair follicle stem cells for regenerative medicine purposes.
Ralf's particular interest is in:
better defining and in manipulating various neuroendocrine pathways established in the human hair follicle (HPA and HPT axis equivalent systems) and in elucidating novel functions of this neuroendocrine activity, such as neuroendocrine controls of mitochondrial activity and biogenesis in human skin, stem cell biology, and wound healing
understanding the controls and functions of hair follicle immune privilege and its disorders that lead to alopecia areata or scarring alopecia
characterizing, selectively labelling, isolating and differentiating various stem cells populations associated with human scalp skin and its appendages
role of clock genes and olfactory receptors in the control of human hair growth and pigmentation
Methodologically, Ralf employs mainly human hair follicle and scalp skin organ culture, K15-GFP+ human epithelial hair follicle stem cells, and immunohistology/immunofluorescence, gene expression profiling, and analyzes the hair and skin phenotype of relevant mouse mutants.
研究兴趣
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Rook's Textbook of Dermatologypp.1-31, (2024)
Marta Bertolini,Jennifer Gherardini,Jeremy Cheret,Majid Alam,Mathias Sulk,Natalia V. Botchkareva, Tamas Biro,Wolfgang Funk, Frieder Grieshaber,Ralf Paus
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2024)
Takahiro Suzuki,Jérémy Chéret, Fernanda S. Dinelli, Ali Rajabi-Estarabadi, Aysun Akhundlu, Dana-Lee Demetrius,Jennifer Gherardini,Aviad Keren,Matthew Harries, Jose Rodriguez-Feliz, Gorana Epstein-Kuka,Wendy Lee,
Journal of Autoimmunity (2024): 103217-103217
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 3 (2024): 697-701.e6
British Journal of Dermatologyno. 6 (2024)
EXPERIMENTAL DERMATOLOGYno. 1 (2024): e14955-e14955
The Journal of investigative dermatologyno. 8 (2023): 1617-1620.e4
Journal of The American Academy of Dermatologyno. 3 (2023): AB8-AB8
Jeremy Cheret, Tara Samra, Samantha D. Verling,Jennifer Gherardini, Jose Rodriguez-Feliz, Alan J Bauman, Celina Amaya Sanchez,Tongyu C Wikramanayake,Xiang-Xi Xu,Ralf Paus.
Journal of Investigative Dermatology (2023)
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