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个人简介
The mission of the Jones lab is to advance our understanding of the relationship between HIV and the human immune system – primarily cytotoxic T-cells and natural killer cells. We are motivated in this both by the desire to contribute to the development of novel therapies aimed at curing HIV infection, and by the recognition that the study of the interplay between HIV and the immune system will continue to yield fundamental biological insights. Reflecting these motivations, our research program spans from basic science through to pre-clinical models of HIV infection, such as humanized mice, through to clinical trials. We also have a particular interest in immunoengineering approaches to both enhancing and studying the immune response to HIV.
A particular area of current emphasis in the lab, is understanding what factors may underlie differential susceptibilities of HIV-infected cells to killing by cytotoxic T-cells. We are exploring this using a bank of clinical samples, along with a library of HIV-specific cytotoxic T-cell clones, using advanced tissue culture techniques, transcriptomics, viral genomics, and cutting-edge approaches to measuring the HIV reservoir.
A particular area of current emphasis in the lab, is understanding what factors may underlie differential susceptibilities of HIV-infected cells to killing by cytotoxic T-cells. We are exploring this using a bank of clinical samples, along with a library of HIV-specific cytotoxic T-cell clones, using advanced tissue culture techniques, transcriptomics, viral genomics, and cutting-edge approaches to measuring the HIV reservoir.
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Yanqin Ren,Szu-Han Huang,Shabnum Patel,Winiffer D Conce Alberto,Dean Magat,Dughan J Ahimovic,Amanda B Macedo, Ryan Durga,Dora Chan, Elizabeth Zale,Talia M Mota,Ronald Truong,
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