基本信息
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职业迁徙
个人简介
Research Experience
Pain
Rats
Research Interests
Somatosensory physiology
Pain mechanisms
Novel analgesic approaches
My laboratory focuses on identifying disrupted function of sensory neurons following injury and exploring novel therapies for pain. We employ combined physiological approaches of patch-clamp electrophysiology for identification of membrane biophysics, single unit recordings by sharp electrode in intact ganglia in vitro and in vivo to evaluate neuronal function in the absence of dissociation, teased fiber recording, and microfluorometry to characterize the cytoplasmic Ca2+ signal that follows membrane activation. These approaches are ideally suited to explore the basic mechanisms of pain. My research has also emphasized the importance of valid behavioral testing as a necessary criterion for relevant pain study, as I am aware from my clinical work of the potential for divergence between animal models and human disease. I as well as other scientists investigating pain mechanisms have come to recognize that there is a major shortfall in translation of these discoveries into therapies. Therefore, my research also explores and develops novel approaches for taking advantage of the extensive backlog of mechanistic discoveries, including targeting the sensory neuron for molecular manipulations, stem cell therapy, and electrical stimulation as treatment modalities.
研究兴趣
论文共 174 篇作者统计合作学者相似作者
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The Journal of clinical investigation (2024)
Tyler B Waltz,Dongman Chao, Eve K Prodoehl, Jonathan D Enders,Vanessa L Ehlers, Bhavya S Dharanikota,Nancy M Dahms,Elena Isaeva,Quinn H Hogan,Bin Pan,Cheryl L Stucky
The Journal of Painno. 4 (2023): 21-21
Research square (2023)
Tyler B Waltz,Dongman Chao,Eve K Prodoehl,Vanessa L Ehlers, Bhavya S Dharanikota,Nancy M Dahms,Elena Isaeva,Quinn H Hogan,Bin Pan,Cheryl L Stucky
bioRxiv : the preprint server for biology (2023)
Arthritis Research & Therapyno. 1 (2022): 1-15
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