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个人简介
Dr. Li's research focuses on the generation of tumor-reactive T cells and B cells for the adoptive immunotherapy of cancer. To sensitize/induce tumor-reactive T cells and B cells in vivo, lymph node cells are primed utilizing as vaccines the genetically modified tumor cells, tumor cells admixed with bacterial adjutants, or antigen/antigen presenting cells. In order to optimize the methods that are capable of expanding lymphoid cells in vitro while maintaining or augmenting their antitumor reactivity, Dr. Li's research effort centers on developing new strategies for T and B cell activation/expansion using monoclonal antibodies and recombinant cytokines, as well as other T cell and/or B cell stimuli. Dr. Li's research effort is also devoted to the identification and characterization of tumor-specific T cell and B cell subsets. This issue is addressed by defining the specific antitumor reactivity of CD4+ cells or CD8+ cells, differentiating Th1/Tc1 versus Th2/Tc2 cytokine responses, studying molecules markers on T or B cells by T cell or B cell subsets. In addition, cancer stem cell model represents a new paradigm for the development of cancer immunotherapy. Conventional cytotoxic chemotherapy and immunologic approaches may kill most of the non-tumorigenic cells in a tumor, but cancer stem cells survive due to their relative high resistance to drugs or non-responsiveness to immunotherapy. Dr. Li's current research approaches involving development of novel therapeutic approaches by immunologically targeting cancer stem cells or by isolating and characterizing tumor associated antigens represent new directions taken in the laboratory.
研究兴趣
论文共 204 篇作者统计合作学者相似作者
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Zhiqiang Mo,Ling Lv,Qicong Mai,Qiao Li,Jian He,Tao Zhang, Jingwu Xu, Jiayan Fang,Ning Shi,Qing Gou,Xiaoming Chen, Jing Zhang,
Journal for immunotherapy of cancerno. 1 (2024)
Yan Lin,Qiao Li, Guangyu Liang, Nanyin Xiao,Jiankun Yang,Xiao Yang,Heng Zhang,Cuntai Zhang,Anding Liu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 181
Shasha Ruan,Ming Lin, Yong Zhu,Lawrence Lum,Archana Thakur,Runming Jin,Wenlong Shao, Yalei Zhang,Yangyang Hu,Shiang Huang,Elaine M. Hurt,Alfred E. Chang,
crossref(2023)
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International journal of cancerno. 7 (2023): 1324-1336
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