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个人简介
Dr Frangogiannis’ research explores the mechanisms of cardiac injury, repair and remodeling. His laboratory has identified key molecular signals responsible for orchestrating the healing response in myocardial infarction. Research has focused on six main directions:
a) The role of chemokine-mediated pathways in cardiac injury, repair and fibrosis.
b) Signals involved in resolution of the inflammatory reaction and in containment of the fibrotic response following infarction.
c) The role of TGF-beta-activated signaling cascades in cardiac repair, remodeling and fibrosis.
d) The role of the dynamic alterations in the composition of the extracellular matrix network in modulating inflammatory pathways and cellular behavior in the injured and remodeling heart.
e) The cell biological mechanisms involved in the pathogenesis of cardiac fibrosis in the cardiomyopathy associated with diabetes and obesity.
f) The role of cardiac pericytes in cardiac repair and in the pathogenesis of fibrosis
The goals of the Frangogiannis laboratory are: i) to dissect the cellular mechanisms and molecular signals involved in the pathogenesis of cardiac remodeling, and ii) to identify novel therapeutic targets for patients with heart failure.
a) The role of chemokine-mediated pathways in cardiac injury, repair and fibrosis.
b) Signals involved in resolution of the inflammatory reaction and in containment of the fibrotic response following infarction.
c) The role of TGF-beta-activated signaling cascades in cardiac repair, remodeling and fibrosis.
d) The role of the dynamic alterations in the composition of the extracellular matrix network in modulating inflammatory pathways and cellular behavior in the injured and remodeling heart.
e) The cell biological mechanisms involved in the pathogenesis of cardiac fibrosis in the cardiomyopathy associated with diabetes and obesity.
f) The role of cardiac pericytes in cardiac repair and in the pathogenesis of fibrosis
The goals of the Frangogiannis laboratory are: i) to dissect the cellular mechanisms and molecular signals involved in the pathogenesis of cardiac remodeling, and ii) to identify novel therapeutic targets for patients with heart failure.
研究兴趣
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Expert opinion on therapeutic targetsno. 1-2 (2024): 45-56
EXPERT OPINION ON THERAPEUTIC TARGETSno. 1-2 (2024): 45-56
Springer eBookspp.61-100, (2023)
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Claudio Humeres, Silvia C. Hernandez-Velasco,Anis Hanna,Izabela Tuleta,Harikrishnan Venugopal,Akihiko Kubota,Nikolaos Frangogiannis
CIRCULATION RESEARCHno. Suppl_1 (2023)
The Journal of Cardiovascular Agingno. 4 (2023)
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