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The Morrell laboratory is studying the molecular mechanisms underlying pulmonary arterial hypertension. In particular our research is focussed on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial pulmonary arterial hypertension (PAH). In addition we are leading large national and international studies to identify novel genetic drivers of PAH and chronic thromboembolic pulmonary hypertension.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
The Morrell laboratory is studying the molecular mechanisms underlying pulmonary arterial hypertension. In particular our research is focussed on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial pulmonary arterial hypertension (PAH). In addition we are leading large national and international studies to identify novel genetic drivers of PAH and chronic thromboembolic pulmonary hypertension.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
研究兴趣
论文共 663 篇作者统计合作学者相似作者
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Bin Liu, Mujahid Azfar, Ekaterina Legchenko,James A West,Shaun Martin,Chris Van den Haute,Veerle Baekelandt,John Wharton,Luke Howard,Martin R Wilkins,Peter Vangheluwe,Nicholas W Morrell,
Cardiovascular research (2024)
Nature Communicationsno. 1 (2024): 1-13
Human molecular genetics (2024)
PULMONARY CIRCULATIONno. 1 (2024): e12346-e12346
American journal of respiratory and critical care medicine (2024)
Yi-Yin Tai,Qiujun Yu,Ying Tang,Wei Sun,Neil J Kelly, Satoshi Okawa,Jingsi Zhao,Tae-Hwi Schwantes-An,Caroline Lacoux,Stephanie Torrino,Yassmin Al Aaraj, Wadih El Khoury,
Circulationno. 21 (2023): 1606-1621
biorxiv(2023)
medRxiv (Cold Spring Harbor Laboratory) (2023)
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