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Monkol received an undergraduate degree in Engineering (Computer Engineering) in 2000 at the University of New South Wales (UNSW) and then worked for IBM for 3.5 years. He returned to UNSW and completed undergraduate degrees in Science (Physiology) and Engineering (Bioinformatics) and received the University Medal in 2007. He completed his PhD (Medicine) at the University of Sydney in 2012 with the thesis topic: Functional differences between alpha-actinin-2 and alpha-actinin-3. Monkol did his post-doctoral training in Daniel MacArthur’s lab based at Massachusetts General Hospital, Harvard Medical School and the Broad Institute.
He was the lead author/analyst for the Exome Aggregation Consortium (ExAC) project that was published in Nature 2016. He went on to lead the NIH funded Broad Center for Mendelian Genomics (CMG) analysis team. As lead analyst, he oversaw the analysis strategy for all major CMG collaborations and organized monthly meetings to foster sharing of new methods and analysis amongst the rare disease community. He also coordinated the data processing and preliminary analysis of NIH Gabriella Miller Kids First (GMKF) cohorts sequenced or reprocessed at the Broad Institute.
Monkol has a strong passion for rare muscle disease research as a patient with Limb Girdle Muscular dystrophy (LGMD2G). During his time in the Broad Institute, he lead the exome/genome analysis of MYOSEQ (European cohort of >1000 LGMD patients) and SeqNMD (an international consortium of undiagnosed rare muscle diseases) which has resulted in novel disease gene discovery.
Monkol received an undergraduate degree in Engineering (Computer Engineering) in 2000 at the University of New South Wales (UNSW) and then worked for IBM for 3.5 years. He returned to UNSW and completed undergraduate degrees in Science (Physiology) and Engineering (Bioinformatics) and received the University Medal in 2007. He completed his PhD (Medicine) at the University of Sydney in 2012 with the thesis topic: Functional differences between alpha-actinin-2 and alpha-actinin-3. Monkol did his post-doctoral training in Daniel MacArthur’s lab based at Massachusetts General Hospital, Harvard Medical School and the Broad Institute.
He was the lead author/analyst for the Exome Aggregation Consortium (ExAC) project that was published in Nature 2016. He went on to lead the NIH funded Broad Center for Mendelian Genomics (CMG) analysis team. As lead analyst, he oversaw the analysis strategy for all major CMG collaborations and organized monthly meetings to foster sharing of new methods and analysis amongst the rare disease community. He also coordinated the data processing and preliminary analysis of NIH Gabriella Miller Kids First (GMKF) cohorts sequenced or reprocessed at the Broad Institute.
Monkol has a strong passion for rare muscle disease research as a patient with Limb Girdle Muscular dystrophy (LGMD2G). During his time in the Broad Institute, he lead the exome/genome analysis of MYOSEQ (European cohort of >1000 LGMD patients) and SeqNMD (an international consortium of undiagnosed rare muscle diseases) which has resulted in novel disease gene discovery.
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crossref(2024)
medRxiv : the preprint server for health sciences (2024)
Siwei Chen,Laurent C. Francioli,Julia K. Goodrich,Ryan L. Collins,Masahiro Kanai,Qingbo Wang,Jessica Alfoldi, Nicholas A. Watts, Christopher Vittal,Laura D. Gauthier,Timothy Poterba,Michael W. Wilson,
NATUREno. 7993 (2024)
Siwei Chen,Laurent C. Francioli,Julia K. Goodrich,Ryan L. Collins,Masahiro Kanai,Qingbo Wang, Jessica Alfoeldi, Nicholas A. Watts, Christopher Vittal,Laura D. Gauthier,Timothy Poterba,Michael W. Wilson,
NATURE (2024)
Rhett G Marchant,Samantha J Bryen,Melanie Bahlo,Anita Cairns, Katherine R Chao, Alastair Corbett,Mark R Davis,Vijay S Ganesh,Roula Ghaoui,Kristi J Jones,Andrew J Kornberg,Monkol Lek,
Annals of clinical and translational neurology (2024)
crossref(2024)
Julie A Jurgens, Brenda J Barry,Wai-Man Chan, Sarah MacKinnon,Mary C Whitman, Paola M Matos Ruiz, Brandon M Pratt,Eleina M England, Lynn Pais,Gabrielle Lemire, Emily Groopman, Carmen Glaze,
medRxiv : the preprint server for health sciences (2024)
Kaiyue Ma, Kenneth Ng,Shushu Huang,Nicole Lake, Jenny Xu, Lin Ge,Keryn Woodman, Katherine Koczwara,Angela Lek,Monkol Lek
biorxiv(2023)
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