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Marc Lajoie has invented a way to reprogram T cells so they can target combinations of antigens rather than just single ones, which should allow them to tackle a much wider range of cancers. “It’s the equivalent of putting a microchip into a cell,” he says. “We can install these new programs and co-opt the cell to make the decisions that we want them to make.”
“We can install these new programs and co-opt the cell to make the decisions that we want them to make.”
Lajoie and colleagues at the University of Washington developed switches made from proteins, which he then used as the basis of a series of logic gates capable of carrying out the same “and,” ”or,” and “not” operations that computer chips do.
Such gates can be tuned to react to different antigens, which allows T cells to target unique combinations of antigens, avoid antigens found on healthy cells, or target cancers that develop resistance due to antigen loss.
“We can install these new programs and co-opt the cell to make the decisions that we want them to make.”
Lajoie and colleagues at the University of Washington developed switches made from proteins, which he then used as the basis of a series of logic gates capable of carrying out the same “and,” ”or,” and “not” operations that computer chips do.
Such gates can be tuned to react to different antigens, which allows T cells to target unique combinations of antigens, avoid antigens found on healthy cells, or target cancers that develop resistance due to antigen loss.
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论文共 51 篇作者统计合作学者相似作者
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