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We have established colon cancer stem cell spheroids from the primary tumors excised from ˜200 patients at Kyoto University Hospital. We have also demonstrated that the chemosensitivity of patients can be predicted by the response of stem cells in culture and/or xenografts. This approach allows prediction of clinical efficacy in a few months, without any burden to patients. Importantly, we can avoid prescribing inefficacious chemotherapeutics to the patients who will not respond to them (Figure 1).
We are clinically applying this method to not only chemotherapeutics that are already approved, but also to those under development. Namely, we reported recently that a subset of colorectal cancer patients may benefit from FGFR inhibitor therapy (Figure 2).
We are clinically applying this method to not only chemotherapeutics that are already approved, but also to those under development. Namely, we reported recently that a subset of colorectal cancer patients may benefit from FGFR inhibitor therapy (Figure 2).
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Yu Li,Teruaki Fujishita,Emi Mishiro-Sato,Yasushi Kojima, Yanqing Niu,Makoto Mark Taketo, Yuya Urano,Tomohisa Sakai,Atsushi Enomoto,Yoshihiro Nishida,Masahiro Aoki
CANCER SCIENCEno. 2 (2024): 401-411
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Tomonori Morimoto, Yukitoshi Takemura, Takemitsu Miura,Takehito Yamamoto,Fumihiko Kakizaki, Hideo An,Hisatsugu Maekawa,Tadayoshi Yamaura,Kenji Kawada,Yoshiharu Sakai, Yoshiaki Yuba,Hiroaki Terajima,
Cancer scienceno. 8 (2023): 3259-3269
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