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The focus of our work lies on the anti-apoptotic proteins, Survivin and XIAP, respectively the determination of the cell localization and the potential association with components of DSB repair (primarily a possible co-localization with yH2AX, Rad51 and BRCA2) through genotoxic stress.
The expression of Survivin and XIAP is increased in various types of tumors, including the malignant glioma grade III and IV (glioblastoma); colorectal cancer (CRC), and correlated with the degree of malignancy. Therefore, the two proteins are specific molecular targets that are suitable for a downregulation in tumor cells. In particular, Survivin presents itself as an important resistant marker in the treatment with ionizing radiation, whereby a direct association of the DSB repair via a non-homologous end-to-end link (non-homologous end joining) could be shown. (Reichert et al. 2011).
This association of cytostatics, which are used in these tumor types together with radiation, has not been investigated yet. Our studies are important both to clarify this potential association and to find out how to overcome the resistance of cytostatics through the use of adjuvant therapy. This therapy is based on small molecule inhibitors of Survivin /XIAP and has already been clinically tested. In addition, we are investigating the epigenetic alterations in the promoter methylation of tumor suppressor XAF-1, an opponent of XIAP and Survivin, as a potential prognostic marker for high-grade gliomas.
The expression of Survivin and XIAP is increased in various types of tumors, including the malignant glioma grade III and IV (glioblastoma); colorectal cancer (CRC), and correlated with the degree of malignancy. Therefore, the two proteins are specific molecular targets that are suitable for a downregulation in tumor cells. In particular, Survivin presents itself as an important resistant marker in the treatment with ionizing radiation, whereby a direct association of the DSB repair via a non-homologous end-to-end link (non-homologous end joining) could be shown. (Reichert et al. 2011).
This association of cytostatics, which are used in these tumor types together with radiation, has not been investigated yet. Our studies are important both to clarify this potential association and to find out how to overcome the resistance of cytostatics through the use of adjuvant therapy. This therapy is based on small molecule inhibitors of Survivin /XIAP and has already been clinically tested. In addition, we are investigating the epigenetic alterations in the promoter methylation of tumor suppressor XAF-1, an opponent of XIAP and Survivin, as a potential prognostic marker for high-grade gliomas.
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Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
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Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger,Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Cellular and molecular life sciences : CMLSno. 10 (2023): 1-19
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger,Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Maja T. Tomicic, Dorthe Aasland, Steffen C. Naumann,Ruth Meise, Christina Barckhausen,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
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