基本信息
浏览量:49
职业迁徙
个人简介
Research
The process of homologous recombination plays essential roles in the mitotic and meiotic cell cycles of most eukaryotic organisms. During meiosis, the programmed formation and processing of double strand breaks by homologous recombination is obligatory to establish the mechanical force between chromosome homologues essential for their segregation. The absence of homologous recombination in meiosis leads to random segregation of homologues at the first meiotic division and formation of aneuploid gametes (spores in yeast).
Meiotic recombination also contributes to genetic diversity by creating new linkage arrangements between genes, or parts of genes. In mitotic cells, double strand breaks form during S-phase by the convergence of replication forks with transient single-strand lesions. These breaks are repaired by homologous recombination to restore the collapsed replication fork. The absence of homologous recombination functions in vertebrates results in the accumulation of chromosome and chromatid breaks during S-phase triggering apoptosis and cell death.
研究兴趣
论文共 138 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Methods in Cell Biology (2024): 35-48
Lorenzo Galanti,Martina Peritore,Robert Gnugge,Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger,Lorraine S. Symington,Petr Cejka,Boris Pfander
NATURE COMMUNICATIONSno. 1 (2024): 2890-2890
Genes & developmentno. 7-8 (2024): 354-354
Nature Communicationsno. 1 (2023)
Nature Communicationsno. 1 (2023): 1-16
Molecular cellno. 8 (2023): 1237-1250.e15
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn