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个人简介
Dr. Farrer’s research has lead to more than 450 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders, most notably Alzheimer disease (AD), substance use disorders (SUDs), age-related macular degeneration (AMD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for AMD, the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) and whole genome/exome sequencing studies for several disorders including AD, SUDs (cocaine, opiates, nicotine, alcohol and cannabis), and AMD. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response.
研究兴趣
论文共 913 篇作者统计合作学者相似作者
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NATURE COMMUNICATIONSno. 1 (2024): 1-15
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Habbiburr Rehman,Ting Fang Alvin Ang,Qiushan Tao, Arielle Lauren Espenilla,Rhoda Au,Lindsay A. Farrer,Xiaoling Zhang,Wei Qiao Qiu
JOURNAL OF ALZHEIMERS DISEASEno. 2 (2024): 621-633
Nature geneticspp.1-17, (2024)
Yixuan Wang,Jinghan Huang,Ting Fang Alvin Ang, Yibo Zhu,Qiushan Tao,Jesse Mez,Michael Alosco,Gerald V. Denis,Anna Belkina, Ashita Gurnani,Mark Ross,Bin Gong,
Exploration of Medicineno. 2 (2024): 193-214
ALZHEIMERS & DEMENTIAno. 2 (2024): 1268-1283
Julie Le Borgne,Lissette Gomez,Sami Heikkinen,Najaf Amin,Shahzad Ahmad,Seung Hoan Choi,Joshua Bis,Benjamin Grenier-Boley, Omar Garcia Rodriguez,Luca Kleineidam,Juan Young, Kumar Parijat Tripathi,
medrxiv(2024)
Laia Montoliu-Gaya,Michael L. Alosco,Eukyung Yhang,Yorghos Tripodis, Daniel Sconzo,Madeline Ally,Lana Groetschel,Nicholas J. Ashton,Juan Lantero-Rodriguez,Mathias Sauer, Barbara Gomes,Johanna Nilsson,
ACTA NEUROPATHOLOGICAno. 1 (2024): 5-5
John S Malamon,John J Farrell,Li Charlie Xia,Beth A Dombroski, Rueben G Das, Jessica Way,Amanda B Kuzma,Otto Valladares,Yuk Yee Leung, Allison J Scanlon, Irving Antonio Barrera Lopez, Jack Brehony,
Life science allianceno. 5 (2024)
Annals of neurology (2024)
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