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个人简介
Dr. Pachman's translational team studies Juvenile Myositis (JM), an often chronic pediatric systemic vasculopathy associated with skin inflammation and proximal muscle weakness of unknown etiology. Her laboratory has identified genetic, immunologic and environmental factors that play a role in the onset of symptoms and govern outcome. RNASeq, miRNA and Gene expression micro array studies of untreated children's diagnostic muscle biopsies identified massive dysregulation of IFN-a induced genes in JDM. Epigenetic and miRNA studies of diagnostic muscle biopsies indicate critical differences associated with disease duration. Dr. Pachman’s search for clinically useful biomarkers of immune activation has identified CD3- natural killer cells, damaged endothelial cells, as well as proteomic markers associated with disease activity. This is of relevance, for with chronic inflammation there is progressive endothelial damage reflected by loss of nailfold capillary end row loops (we have developed a quantitative system of nailfold capillary analysis). We maintain a patient-derived CureJM Registry now available in REDCap as well as a JM Repository containing diagnostic muscle and skin biopsies, sequential sera, peripheral blood lymphocytes and dystrophic calcifications samples keyed the bio-informatics system for over 600 children with Juvenile Myositis. In summary, this extensive and intensive research effort broadens the clinical, genetic and immunological characterization of the child with JM, which will be a critical aid to guide current therapy and may lead to novel targeted interventions.
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Clinical Immunology Communications (2024): 20-25
Peyman Hosseinzadeh Kassani,Louis Ehwerhemuepha, Chloe Martin-King, Ryan Kassab,Ellie Gibbs,Gabrielle Morgan,Lauren M. Pachman
Pediatric Researchno. 4 (2024): 981-987
Journal of autoimmunity (2023): 103061
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The Journal of Immunologyno. 1 (2023): 247.08-247.08
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Clinical Immunology Communications (2023): 42-45
Christopher Costin,Amer Khojah,Elisa Ochfeld,Gabrielle Morgan, Saravanan Subramanian, Marisa Klein-Gitelman,Xiao-Di Tan,Lauren M Pachman
Pediatric rheumatology online journalno. 1 (2023): 1-9
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