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The Vukovic laboratory investigates how brain function is sculpted and influenced by the immune system. Specifically, we examine the role of brain’s main resident immune cell population (i.e. microglia), as well as various peripheral immune cells, on learning and memory in mice. We are interested in defining the contribution of immune cells to such higher cognitive tasks, including for neuroinflammatory conditions where learning and memory deficits can occur, e.g. following traumatic brain injury, cancer treatment, and ageing. We have established an array of genetic and pharmacological tools alongside robust behavioural assays to directly probe the function of these immune cells in both the healthy and diseased brain. The ultimate goal of our work is to link cellular and molecular events to altered behaviour, and to harness the brain’s intrinsic regenerative potential for stimulating optimal cognitive function.
Dr Vukovic demonstrated that microglia can exert a dual and opposing influence over adult neurogenesis (the birth of new neurons) in the hippocampus under different physiological conditions, namely exercise and ageing, and that signalling through the chemokine receptor, CX3CR1, critically contributes towards this (Vukovic et al., 2012, J Neurosci). Dr Vukovic also generated novel evidence that ongoing neurogenesis in the adult hippocampus is critical for new learning but does not play a role in memory recall (Vukovic et al., 2013, J Neurosci).
Dr Vukovic was awarded an ARC Discovery Early Career Researcher Award (2015-2018) and was jointly appointed as a group leader by the UQ School of Biomedical Sciences (SBMS) and QBI in 2015. She heads the Neuroimmunology and Cognition team investigating the interactions between the brain and the immune system in health and disease.
Currently, the group is working on three main projects:
Identification of microglia-derived molecules that support neuronal survival and stimulate neural stem/progenitor cell expansion
Characterisation of immune cell contribution to changes in neuronal connectivity
Immune cell responses to cancer treatment, and their effect on learning and memory
Dr Vukovic demonstrated that microglia can exert a dual and opposing influence over adult neurogenesis (the birth of new neurons) in the hippocampus under different physiological conditions, namely exercise and ageing, and that signalling through the chemokine receptor, CX3CR1, critically contributes towards this (Vukovic et al., 2012, J Neurosci). Dr Vukovic also generated novel evidence that ongoing neurogenesis in the adult hippocampus is critical for new learning but does not play a role in memory recall (Vukovic et al., 2013, J Neurosci).
Dr Vukovic was awarded an ARC Discovery Early Career Researcher Award (2015-2018) and was jointly appointed as a group leader by the UQ School of Biomedical Sciences (SBMS) and QBI in 2015. She heads the Neuroimmunology and Cognition team investigating the interactions between the brain and the immune system in health and disease.
Currently, the group is working on three main projects:
Identification of microglia-derived molecules that support neuronal survival and stimulate neural stem/progenitor cell expansion
Characterisation of immune cell contribution to changes in neuronal connectivity
Immune cell responses to cancer treatment, and their effect on learning and memory
研究兴趣
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Aging cellpp.e14172-e14172, (2024)
Nguyen Thi Khanh Nhu,M. Arifur Rahman,Kelvin G. K. Goh, Seung Jae Kim,Minh-Duy Phan,Kate M. Peters,Laura Alvarez-Fraga,Steven J. Hancock, Chitra Ravi, Timothy J. Kidd,Matthew J. Sullivan,Katharine M. Irvine,
Rachael C Adams,Dylan Carter-Cusack, Genesis T Llanes,Christopher R Hunter,Janaki Manoja Vinnakota,Marc Ruitenberg,Jana Vukovic,Patrick Bertolino,Kirat K. Chand,Julie A. Wixey, Samuel P Nayler,Geoffrey R Hill,
Resuscitation Plus (2023): 100426-100426
Samreen N. Shaikh,Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart,Glenda C. Gobe, Abate A. Bashaw,Oliver Rawashdeh,Seung Jae Kim,Jana Vukovic
JOURNAL OF NEUROINFLAMMATIONno. 1 (2023): 1-20
BRAIN BEHAVIOR AND IMMUNITY (2023): 37-50
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