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Using novel in vivo conditional deletions in the mouse i’m aiming to understand the molecular mechanisms by which the imprinted insulin-like growth factor 2 (Igf2) gene regulates the normal development of placental vasculature during late gestation;
I’m also studying the epigenetic basis of the so-called “nutritional programming” of adult diseases, a phenomenon by which suboptimal diet during critical periods of development is associated with risk of metabolic diseases such as type 2 diabetes and obesity in later life. I’m particularly interested in understanding the role of altered promoter-enhancer interactions in this phenomenon.
I’m also studying the epigenetic basis of the so-called “nutritional programming” of adult diseases, a phenomenon by which suboptimal diet during critical periods of development is associated with risk of metabolic diseases such as type 2 diabetes and obesity in later life. I’m particularly interested in understanding the role of altered promoter-enhancer interactions in this phenomenon.
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Neuronno. 23 (2023): 3819-3836.e8
HORMONE RESEARCH IN PAEDIATRICS (2023): 27-27
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Ionel Sandovici,Borbala Mifsud,Amy Emery,Pawan Gulati,Katherine A Kentistou,Ayesha Banu, Niamh Campbell,Bryn S Hardwick, Alex T Crooks,Denise S Fernandez-Twinn, Lais V Mennitti, Luma Srour,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cell metabolismno. 7 (2023): 1195-1208.e6
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Ionel Sandovici,Denise S. Fernandez-Twinn, Niamh Campbell,Wendy N. Cooper,Yoichi Sekita,Ilona Zvetkova,David Ferland-McCollough,Haydn M. Prosser,Lila M. Oyama,Danilo Cimadomo,Karina Barbosa de Queiroz, Cecilia S.K. Cheuk,
biorxiv(2022)
STAR protocolsno. 4 (2022): 101721-101721
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