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His research at NCI centered on working out how the body metabolizes environmental carcinogens, such as one of the most common in our environment, benzopyrene, which occurs in tobacco smoke, auto exhaust, and other smoke-producing sources. His laboratory identified the genes for the many cytochrome P-450 enzymes that detoxify various environmental carcinogens. These enzymes break down hazardous chemicals into molecules that can be safely excreted by the kidney. He developed the foundation for a genetic profile that could screen individuals for susceptibility to certain carcinogens, foods, and drugs.
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论文共 31 篇作者统计合作学者相似作者
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Encyclopedia of Drug Metabolism and Interactions (2012)
Charles L. Crespi, Dorothy T. Steimel, Bruce W. Penman,Kenneth R. Korzekwa,Pedro Fernandez-Salguero,Jeroen T. M. Buters,Harry V. Gelboin,Frank J. Gonzalez,Jeffrey R. Idle,Ann K. Daly
FRANK J. GONZALEZ, BALTHAZAR J. SCHMID, MORIO UMENO,O. WESLEY MCBRIDE,JAMES P. HARDWICK,URS A. MEYER,HARRY V. GELBOIN,JEFFREY R. IDLE
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