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Research:
Our laboratory studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism. This fundamental question is central to tissue development, maintenance and regeneration, and has implications for every aspect of adult physiology ranging from response to stress, development of diseases, and biology of aging. We are interested in identifying the mechanisms that control HSC activity in normal and a range of deregulated conditions, with the goal of identifying affected genes and pathways that could be used to develop new therapies to treat human myeloid malignancies and help combat physiological aging. Towards this end, we are employing a variety of cross-disciplinary approaches using mouse models and human samples.
Research Interests:
Hematopoietic stem cell biology,Myeloid malignancies,Stem cells in tissue homeostasis and aging
Our laboratory studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism. This fundamental question is central to tissue development, maintenance and regeneration, and has implications for every aspect of adult physiology ranging from response to stress, development of diseases, and biology of aging. We are interested in identifying the mechanisms that control HSC activity in normal and a range of deregulated conditions, with the goal of identifying affected genes and pathways that could be used to develop new therapies to treat human myeloid malignancies and help combat physiological aging. Towards this end, we are employing a variety of cross-disciplinary approaches using mouse models and human samples.
Research Interests:
Hematopoietic stem cell biology,Myeloid malignancies,Stem cells in tissue homeostasis and aging
研究兴趣
论文共 166 篇作者统计合作学者相似作者
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Catharina Conrad,Melia Magnen, Jessica Tsui, Harrison Wismer, Mohammad Naser, Urmila Venkataramani,Bushra Samad, Simon J Cleary,Longhui Qiu,Jennifer J Tian, Marco De Giovanni,Nicole Mende,
Research square (2024)
Amélie Collins,James W Swann, Melissa A Proven,Chandani M Patel,Carl A Mitchell, Monica Kasbekar,Paul V Dellorusso,Emmanuelle Passegué
Cellno. 6 (2024): 1402-1421.e21
Nature Reviews Immunologypp.1-18, (2024)
Cell Stem Cell (2024)
EXPERIMENTAL HEMATOLOGY (2023): S99-S99
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SSRN Electronic Journalno. 8 (2023)
Cell stem cellno. 11 (2023): 1403-1420
Alexander C Bashore,Hanying Yan,Chenyi Xue,Lucie Y Zhu,Eunyoung Kim, Thomas Mawson, Johana Coronel,Allen Chung,Sebastian Ho, Leila S Ross, Michael Kissner,Emmanuelle Passegué,
medRxiv : the preprint server for health sciencesno. 4 (2023): 930-945
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