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We found that bona fide pathogens evade these defenses. Therefore, to study basic components of innate immunity we pioneer the use of environmental bacteria with pathogenic potential that have not adapted to evade mammalian immunity. These “pathogens” are experimental tools that reveal previously under-appreciated aspects of innate immunity. We find that environmental pathogens are useful tools with which to study the innate immune system, for example, we study pathogens such as Chromobacterium violaceum that infects patients with chronic granulomatous disease (who carry defects in the NADPH oxidase and cannot generate reactive oxygen in the phagosome).
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biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Cell death and differentiationno. 5 (2023): 1097-1154
Carissa K. Harvest,Taylor J. Abele,Chen Yu,Cole J. Beatty, Megan E. Amason, Zachary P. Billman,Morgan A. DePrizio, Fernando W. Souza,Carolyn A. Lacey,Vivien I. Maltez,Heather N. Larson,Benjamin D. McGlaughon,
Nature communicationsno. 1 (2023): 6686-6686
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