Deepak Srivastava
Distinguished Professor
Srivastava Lab
Gladstone Institute of Cardiovascular Disease, University of California San Francisco;Department of Pediatrics, University of California San Francisco;Department of Biochemistry and Biophysics, University of California San Francisco
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基本信息
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个人简介
Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.
研究兴趣
论文共 799 篇作者统计合作学者相似作者
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Nature Cardiovascular Researchno. 3 (2024): 317-331
Circulation. Genomic and precision medicineno. 3 (2023): 224-231
International immunopharmacology (2023): 109741-109741
Tomohiro Nishino,Deepak Srivastava
NATURE CARDIOVASCULAR RESEARCHno. 12 (2023): 1127-1128
Biological Psychiatryno. 2 (2023): 103-105
Frontiers in molecular neuroscience (2023): 1191323
Hippocampusno. 4 (2023): 322-346
bioRxiv : the preprint server for biology (2023)
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