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Our goal is to understand how mammalian chromosomes are organized within the nucleus to carry out their functions. DNA replication provides an excellent forum in which to study chromosome structure and function. Structural and functional units of chromosomes replicate coordinately, often through the synchronous firing of clusters of replication origins that encompass domains of approximately 0.5 Mb. Each of these replication domains is programmed to replicate at a specific time during S-phase. In general, transcriptionally active (euchromatin) domains replicate early in S-phase, and transcriptionally silent (heterochromatin) domains replicate late. Programmed changes in replication timing accompany key stages of animal development and are often coupled to changes in gene expression. Our working hypothesis is that structural, functional, and replication domains share topographical boundaries and represent basic units of chromosome organization. We would like to understand what regulates where and when replication begins, how developmental cues communicate with the cell-cycle machinery to elicit changes in the program for replication and how that program is disrupted in cancer.
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论文共 268 篇作者统计合作学者相似作者
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Lorenzo Corazzi,Vivien S Ionasz,Sergej Andrejev, Li-Chin Wang,Athanasios Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna J M Marx, Jonas Henkenjohann, Michael M Allers,David M Gilbert,
Proceedings of the National Academy of Sciences of the United States of Americano. 16 (2024): e2313440121-e2313440121
Omid Gholamalamdari,Tom van Schaik,Yuchuan Wang, Pradeep Kumar,Liguo Zhang,Yang Zhang, Gabriela A Hernandez Gonzalez,Athanasios E Vouzas,Peiyao A Zhao,David M Gilbert,Jian Ma,Bas van Steensel,
bioRxiv : the preprint server for biology (2024)
Tsunetoshi Nakatani, Tamas Schauer, Luis Altamirano-Pacheco,Kyle N. Klein, Andreas Ettinger, Mrinmoy Pal,David M. Gilbert,Maria-Elena Torres-Padilla
Natureno. 7994 (2024): 401-409
Molecular cellno. 15 (2023): 2624-2640
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Jesse L Turner,David M. Gilbert,Ferhat Ay, Laura Hinojosa-Gonzalez,Athanasios Vouzas,Takayo Sasaki, Cheryl A Fitch,Amber N Brown,Karen E Alexander, Mariella S Soto,Abhijit Chakraborty
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Current opinion in genetics & development (2023): 102031-102031
Meng Zhang, Mary Elisabeth Ehmann, Srija Matukumalli,Aashutosh Girish Boob,David M. Gilbert,Huimin Zhao
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