基本信息
浏览量:5
职业迁徙
个人简介
My Research
KEYWORDS
oncogene function in pancreatic cancer, signal transduction, ras function, inflammation, ras signaling
SUMMARY
The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.
KEYWORDS
oncogene function in pancreatic cancer, signal transduction, ras function, inflammation, ras signaling
SUMMARY
The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.
研究兴趣
论文共 274 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mansour E. Riachi,Carolina G. Alcantara Hirsch, Anthony Sorrentino, Erica Ma, Beny Shapiro, Christopher L. Wolfgang,Dafna Bar-Sagi
Gastroenterologyno. 5 (2024): S-1809-S-1810
Charles Swanton, Elsa Bernard, Chris Abbosh,Fabrice André,Johan Auwerx,Allan Balmain,Dafna Bar-Sagi,René Bernards,Susan Bullman,James DeGregori, Catherine Elliott,Ayelet Erez,
Cellno. 7 (2024): 1589-1616
CANCER RESEARCHno. 2 (2024)
Mansour E. Riachi,Carolina G. Alcantara Hirsch, Erica Ma, Beny Shapiro, Ammar Javed, Christopher L. Wolfgang,Dafna Bar-Sagi
CANCER RESEARCHno. 2 (2024)
Anthony Sorrentino, Carolina Alcantara-Hirsch, Beny Shapiro, Erica Ma, Ammar Javed,Christopher Wolfgang,Dafna Bar-Sagi
CANCER RESEARCHno. 2 (2024)
CANCER RESEARCHno. 2 (2024)
crossref(2023)
Cancer Researchno. 7_Supplement (2023): 3441-3441
crossref(2023)
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn