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个人简介
The major focus of the Lindsley laboratory is drug discovery and medicinal chemistry. Students in my lab will collaborate with other members of the Pharmacology, Drug Metabolism and Clinical Pharmacology departments to pursue small molecule hits from high throughput screens, perform lead optimization studies to develop structure-activity-relationships (SAR) and ultimately deliver small molecules with acceptable properties to validate novel targets/mechanisms in in vivo animal models of target diseases. The molecular targets of interest are kinases, GPCRs, ion channels, nuclear hormone receptors and protein-protein interactions, with an emphasis on allosteric modulation as opposed to classical agonism/antagonism. Therapeutic areas of interest span cancer, neuroscience (schizophrenia, anxiety, pain, sleep, Parkinson’s disease) and endocrinology (diabetes, obesity). Students will be exposed to every phase of classical drug discovery. As a member of ther Vanderbilt Institutue of Chemical Biology, training in my laboratory will be broad and involve organic synthesis, medicinal chemistry, pharmacology and drug metabolism. For many programs in the neuroscience area, students will have the opportunity to also develop radioligands for binding assay development and PET tracers for imaging studies.
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论文共 1097 篇作者统计合作学者相似作者
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Navoda Jayakodiarachchi, Mallory A Maurer, Daniel C Schultz,Cayden J Dodd,Analisa Thompson Gray,Hyekyung P Cho, Olivier Boutaud,Carrie K Jones,Craig W Lindsley,Aaron M Bender
ACS medicinal chemistry lettersno. 2 (2024): 302-309
Shannon T Smith, Jackson B Cassada, Lukas Von Bredow, Kevin Erreger, Emma M Webb, Trevor A Trombley, Jacob J Kalbfleisch,Brian J Bender, Irene Zagol-Ikapitte, Valerie M Kramlinger, Jacob L Bouchard, Sidnee G Mitchell,
ACS pharmacology & translational scienceno. 4 (2024): 1086-1100
JOURNAL OF ORGANIC CHEMISTRYno. 5 (2024): 3500-3508
Nicole E Chambers, Annique MClune,Michael Coyle, Ashley Centner, Jordan Sergio, Isabella Del Priore, Kathryn Lanza,Craig W Lindsley,P. Jeffrey Conn,Christopher Bishop
crossref(2024)
JOURNAL OF MEDICINAL CHEMISTRYno. 7 (2023): 867-867
Assay and drug development technologiesno. 3 (2023): 89-96
Journal of Medicinal Chemistryno. 4 (2023): 2209-2210
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Journal of medicinal chemistryno. 16 (2023): 11027-11039
Aidong Qi, Haley E Kling, Natasha Billard,Alice L. Rodriguez, Li Peng,Jonathan W. Dickerson,Julie L. Engers,Aaron M. Bender,Mark S. Moehle,Craig W. Lindsley,Jerri M. Rook,Colleen M. Niswender
Molecular Pharmacologyno. 5 (2023): 195-202
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