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Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.
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OBESITYno. 2 (2024): 304-314
Respiratory Researchno. 1 (2024): 1-10
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISMno. 4 (2024): e1345-e1358
Hao-Wei Chang,Evan M. Lee,Yi Wang,Cyrus Zhou, Kali M. Pruss, Suzanne Henrissat,Robert Y. Chen, Clara Kao,Matthew C. Hibberd,Hannah M. Lynn,Daniel M. Webber, Marie Crane,
Diego Hernandez-Saavedra,J. Matthew Hinkley,Lisa A. Baer,Kelsey M. Pinckard,Pablo Vidal,Shinsuke Nirengi,Andrea M. Brennan,Emily Y. Chen,Niven R. Narain, Valerie Bussberg,Vladimir V. Tolstikov, Michael A. Kiebish,
ISCIENCEno. 3 (2024): 109083-109083
Somenath Datta, Brett M. Antonio,Nathan H. Zahler, Jonathan W. Theile, Doug Krafte,Hengtao Zhang,Paul B. Rosenberg,Alec B. Chaves,Deborah M. Muoio,Guofang Zhang,Daniel Silas,Guojie Li,
JOURNAL OF CLINICAL INVESTIGATIONno. 5 (2024)
Liora S. Katz,Gabriel Brill,Peng Wang, Luca Lambertini, Pili Zhang,Jonathan M. Haldeman,Hongtao Liu,Christopher B. Newgard,Andrew F. Stewart,Adolfo Garcia-Ocana,Donald K. Scott
MOLECULAR METABOLISM (2024)
Sinthu Pathmanapan,Raymond Poon, Tomasa Barrientos De Renshaw,Puviindran Nadesan,Makoto Nakagawa, Gireesh A. Seesankar,Adrian Kwan Ho Loe,Hongyuan H. Zhang,Joan J. Guinovart,Jordi Duran,Christopher B. Newgard,Jay S. Wunder,
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