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I have a long-standing interest in on the biogenesis of organelles and in particular the family of organelles specific to plants, known as plastids. This family includes a divers set of organelles that perform an extensive set of biochemical reactions including the process of photosynthesis, which takes place in chloroplasts. This diverse metabolic activity is the enabled via the import of several thousand nuclear encoded proteins from the cytosol. This targeting and import process is critical to many if not most of the key metabolic processes associated with plants. We are specifically interested in how chloroplast destined precursors are targeted, recognized and translocated into the plastid via two translocons, TIC and TOC, that are found in the chloroplast inner and outer envelope membranes, respectively. This process is mediated by selective recognition of the transit peptide by one or more of the TOC components. We are working to explain the biochemistry and biophysics of how these proteins are translocated across the plastid membranes.
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Yue Zhou, Jawhar H Syed,Dmitry A Semchonok, Edward Wright,Fotis L Kyrilis,Farzad Hamdi,Panagiotis L Kastritis,Barry D Bruce,Todd B Reynolds
The Journal of biological chemistryno. 6 (2023): 104756
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Christopher Espinoza-Araya,Ricardo Starbird, E Senthil Prasad,Renugopalakrishnan Venkatesan,Ashok Mulchandani,Barry D Bruce,Claudia C Villarreal
Biochimica et biophysica acta. Bioenergeticsno. 4 (2023): 148985-148985
Alexandra H Teodor, Stephanie Monge,Dariana Aguilar,Alexandra Tames, Roger Nunez, Elaine Gonzalez,Juan J Montero Rodríguez,Jesse J Bergkamp,Ricardo Starbird,Venkatesan Renugopalakrishnan,Barry D Bruce,Claudia Villarreal
Plant Communicationsno. 1 (2022): 100248
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