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The Göttgens group uses a combination of experimental and computational approaches to study how transcription factor networks control the function of blood stem cells and how mutations that perturb such networks cause leukaemia. This integrated approach has resulted in the discovery of new combinatorial interactions between key blood stem cell regulators, as well as experimentally validated computational models for blood stem cells. Current research focuses on (i) single cell genomics of early blood development, (ii) modelling the transcriptional landscape of blood stem and progenitor cell differentiation, (iii) transcriptional consequences of leukaemogenic mutations in leukaemia stem/progenitor cells, and (iv) molecular characterisation of human blood stem/progenitor cell populations used in cell and gene therapy protocols.
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论文共 382 篇作者统计合作学者相似作者
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EUROPEAN JOURNAL OF IMMUNOLOGYno. 1 (2024): e2350633-e2350633
Ivan Imaz-Rosshandler,Christina Rode,Carolina Guibentif, Luke T. G. Harland,Mai-Linh N. Ton, Parashar Dhapola,Daniel Keitley,Ricard Argelaguet,Fernando J. Calero-Nieto, Jennifer Nichols,John C. Marioni,Marella F. T. R. de Bruijn,
DEVELOPMENTno. 3 (2024)
Iwo Kucinski,Joana Campos,Melania Barile, Francesco Severi, Natacha Bohin, Pedro N Moreira, Lewis Allen,Hannah Lawson,Myriam L R Haltalli,Sarah J Kinston,Dónal O'Carroll,Kamil R Kranc,
Cell stem cellno. 2 (2024): 244-259.e10
Nature Structural & Molecular Biologyno. 1 (2024): 1-13
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nature Cell Biologyno. 7 (2023): 1061-1072
引用6浏览0WOSNATURE引用
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Luke Harland, Bart Theeuwes, Alexandra Bisia,Mai-Linh Ton,Ricard Argelaguet,Stephen Clark,Tim Lohoff,Nicola Wilson,Wolf Reik, Elizabeth Robertson,Bertie Gottgens
EXPERIMENTAL HEMATOLOGY (2023): S89-S89
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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